In 1309 the Byzantine era came to an end when the island was occupied by forces of the Knights Hospitaller. Under the rule of the newly named "Knights of Rhodes", the city was rebuilt into a model of the European medieval ideal. Many of the city's famous monuments, including the Palace of the Grand Master, were built during this period.
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The strong walls which the Knights had built withstood the attacks of the Sultan of Egypt in 1444, and of Mehmed II in 1480. Ultimately, however, Rhodes fell to the large army of Suleiman the Magnificent in December 1522. The few surviving Knights were permitted to retire to the Kingdom of Sicily. The Knights would later move their base of operations to Malta.
The island was thereafter a possession of the Ottoman Empire for nearly four centuries. The Rhodes blood libel in February 1840 was one of many false accusations against the Jews of Europe, in which the Jews of Rhodes were accused of ritually murdering a Christian boy.
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